一、基本信息
刘应保 讲师 博士
Email : liuyingbao@yangtzeu.edu.cn
二、教育经历
2001/09 - 2006/06 河南科技学院,园林园艺学院 园艺,学士
2007/09 - 2010/07 西北农林科技大学,生命科学学院 生物化学与分子生物学,硕士;
2010/09 -2014/06 西北农林科技大学,生命科学学院 微生物学,博士;
三、开设课程:
本科:微生物学、生物信息学、基因工程与分子生物学、分子病毒学;
研究生:分子病毒学
四、科研状况
1科研项目
(1)国家自然科学基金青年基金项目,31701573,活性氧介导磁场对红曲色素和桔霉素合成的双向调控机制,2018/01-2020/12,24万元,在研,主持;
(2)国家自然科学基金青年基金项目,31501453,基于pacC信号途径研究pH调控红曲色素合成和分泌的分子机制,2015/01-2017/12,22万元,在研,参加;
(3)国家自然科学基金面上项目,31270078,谷氨酸棒杆菌对木质纤维素糖化液中酚类抑制物质的耐受机理研究,2013/01 – 2016/12, 72万元,已结题,参加;
(4)国家自然科学基金面上项目,31170100,基于双分子互补的细菌动态蛋白相互作用网络技术研究,2012/01-2015/12,61万元,已结题,参加;
(5)国家自然科学基金面上项目,31170121,假结核耶尔森氏菌VI型分泌系统的动力学分泌机制研究,2012/01-2015/12,60万元,已结题,参加。
2论文
(1) Yingbao Liu, Xiaobing Yang, Yajie Yin, Jinshui Lin, Can Chen, Junfeng Pan, Meiru Si, Xihui Shen,Mycothiol protects Corynebacterium glutamicum against acid stress via maintaining intracellular pH homeostasis, scavenging ROS, and S-mycothiolating MetE,Journal of General and Applied Microbiology,2016,62(3):144~153(SCI)
(2) Yingbao Liu, Can Chen, Muhammad Tausif Chaudhry, Meiru Si, Lei Zhang, Yao Wang, Xihui Shen,Enhancing Corynebacterium glutamicum robustness by over-expressing a gene, mshA, for mycothiol glycosyltransferase,Biotechnology Letters,2014,36(7):1453~1459(SCI)
(3) Yingbao Liu, Mingxiu Long, Yajie Yin, Meiru Si, Lei Zhang, Zhiqiang Lu, Yao Wang, Xihui Shen,Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum,Archives of Microbiology,2013,195(6):419~429(SCI)
(4) Chuanzhou Liang, Zhonghui Lan, Xu Zhang, Yingbao Liu,Mechanism for the primary transformation of acetaminophen in a soil/water system,Water Research,2016,98:215~224(SCI)
(5) Yunlei Wan, Jialan Zhang, Hongxia Han,Li Li, Yingbao Liu, Mengxiang Gao,Citrinin-producing capacity of Monascus purpureus in response to low −frequency magnetic fields,Process Biochemistry,2017,53:25~29(SCI)
(6) Meiru Si, Yixiang Xu, Tietao Wang, Mingxiu Long, Wei Ding, Can Chen, Xinmeng Guan, Yingbao Liu, Yao Wang, Xihui Shen, Shuangjiang Liu,Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems in the response to oxidative stress,Biochemical Journal,2015,469:45~57(SCI)
(7) Meiru Si, Lei Zhang, Zhifang Yang, Yixiang Xu, Yingbao Liu, Chengying Jiang, Yao Wang, Xihui Shen, Shuangjiang Liu,NrdH Redoxin enhances resistance to multiple oxidative stresses by acting as a peroxidase cofactor in Corynebacterium glutamicum,Applied and Environmental Microbiology,2014,80(5):1750~1762(SCI)
(8) Lei Zhang, Xihui Shen, Yingbao Liu, Shiqing Li,Nafulsella turpanensis gen. nov., sp. nov., a member of the phylum Bacteroidetes isolated from soil.,International Journal of Systematic and Evolutionary Microbiology,2013,63(Pt 5):1639~1645(SCI)
(9) 郑文亮,李边征华,刘应保,王晓宇,刘虎岐,淡色库蚊XND-P450基因cDNA全长克隆及表达,西北农林科技大学学报(自然科学版),2014,(05):211~216(核心)
(10)刘虎岐,刘应保,宋云鹏,段晓雷,程鸟鸟,淡色库蚊氯菊酯抗性相关基因PR-OP全长cDNA的克隆及生物信息学分析,西北农林科技大学学报(自然科学版),2010,(09):109~117(核心)
(11) 蔺晓丽,徐胜娟,刘应保,郭建春,王瑶,根癌农杆菌Ⅵ型分泌系统关键组分ClpⅤ型ATPase基因表达及活性位点分析,基因组学与应用生物学,2011,(02):136~144(核心)
3专利:
(1)国家发明专利:一株可高效降解木质素的乙酸钙不动杆菌(CN201410193429.7),第三;
(2)国家发明专利专利:基于细菌荧光素酶BRET技术检测蛋白质相互作用的方法(CN201310413981.8),第六;
(3)国家发明专利:增强型单体细菌荧光素酶基因luxAB及其应用(CN201310073405.3),第五